This history is focused on the tuna industry in the United States (U.S.) and covers tuna captured in the Eastern, Central, and Western Pacific Oceans, and tuna processing on the U.S. West Coast, Puerto Rico, and American Samoa. This is a brief account of the changes, improvements, and regulations in the tuna capture and processing business in the last 100 years. As the tuna industry changed and modernized, new solutions were needed for new problems. While these changes and resulting problems may or may not have been foreseen, they had to be addressed for political, societal, or food safety reasons. The review of the capture side of the business will include fishing regulations, Regional Fisheries Management Organizations (RFMOs), marine mammal interactions, mercury issues, and fish preservation from catch to cannery. The review of the processing side will cover canned product food safety, Hazard Analysis Critical Control Points (HACCP) regulations and policies, Good Manufacturing Practices (GMPs), histamine regulations, controlling salt and sodium in the tuna meat, Low Acid Canned food regulations, and some notable canned tuna recalls.