Sue Tetef has 30 years of experience in nursing, 28 in critical care, 15 in nursing research and education, and 10 in CRPS research. She spent the majority of her career as an educator and nurse researcher with publications related to nursing and health care. In addition, she had a Legal Nurse Consulting (LNC) business in which she was an expert witness in CRPS-related cases. She was diagnosed with cold CRPS type II in 2016 and has multiple publications related to CRPS and its comorbidities. This handbook may help you rethink what CRPS really is—namely, a systemic disease that can affect any body system or organ—and learn how it functions as a disease , not a syndrome . This handbook is meant to clarify any misinformation about CRPS that you might have and decrease the helplessness, hopelessness, and frustration that comes with having a “rare” disease like CRPS. This information will help explain some of the “ why ” in CRPS, including autonomic nervous system (ANS) dysfunction, neuroinflammation, and central sensitization (CS), which play a major role in CRPS and its comorbidities. The handbook also discusses CRPS diagnostic criteria, risk factors, diagnostic tests, systemic comorbidities, prevention and treatment options, patient accountability and responsibility, and the importance of documentation in the patient’s medical record. The purpose of this handbook is to share information and to educate and support people who have been diagnosed with CRPS, as well as their family and friends. This information may help you understand what someone is going through who is suffering from this disease and give you the tools to help them. I would like to take a moment to personally thank all of the friends, family members, and others who are reading this. It says so much when you take the time and effort to learn about CRPS, including understanding the disease and how best to help those suffering from it.