#1 Dermatologist Recommended Coverage Brand Dermablend brings you Loose Setting Powder, the ultimate step to lock in makeup for up to 16 hours of smudge and transfer-resistant wear. This weightless micronized powder is an essential to flawlessly set foundation and concealer while mattifying skin. Dermablend Loose Setting Powder is transparent upon application and works for all skin types and skin tones. Cruelty-free.