Design with Life chronicles the breakthroughs and projects of a nonprofit that is defining resolute new directions in socio-ecological design and other deep-seated intersections of synthetic biology, architecture, and urban systems. In the challenging context of accelerating climate dynamics, the core discipline of architectural design is evolving and embracing new forms of action. New York-based nonprofit Terreform ONE has established a distinctive design tactic that investigates projects through the regenerative use of natural materials, science, and the emergent field of socio-ecological design. This kind of design approach uses actual living matter (not abstracted imitations of nature) to create new functional elements and spaces. These future-based actions are not only grounded in social justice, but are also far-reaching in their application of digital manufacturing and maker culture. Terreform ONE tackles urgent environmental and urban social concerns through the integrated use of living materials and organisms. "Design with Life is a book that made me smile and hope, that made me marvel at the inventiveness of the forms and feel seduced by a biophilic and technomorphic Garden of Eden rising out of the ruins of our soon-to-be-drowned cities. I do not know enough science to be able to judge whether any of this will work, but if architecture is going to help save our planet, I hope it does so with forms as beautiful as those Joachim and Terreform ONE create." - ARCHITECT magazine Terreform ONE is a research intensive architecture and urban design nonprofit organization founded by Mitchell Joachim and Maria Aiolova in New York City. Terreform ONE engages in a diverse range of work, from large scale master plans and socio-ecological buildings to synthetic biology and speculative prototypes to save organisms from endangerment.