Through the millennia, our human evolution prospered through a dialogue with nature. We learned to pay attention to the sounds, rhythms and textures of nature and bring ourselves into harmony with them. These were survival skills. We created a unique niche for ourselves but became enamoured with our ingenuity. We have stopped listening, and the dialogue is fading. We are trying to adapt to an artificial social and physical environment. It is a synthetic artefact of our own making, not designed to nourish human or non-human life. Adjusting to this environment ignores the wisdom of the past and creates disease, depression and environmental destruction. Much of the confusion about these issues is invented to promote political or commercial agendas. Macrobiome cuts through these mythologies using science, ecology, ancient wisdom and common sense. A new human synergy with nature is required. A reassessment of popular narratives and a map for renewal are essential. This book explores the impact of human activity on the environment, human and non-human health and society. It will appeal to any reader who is interested in avoiding the threats to the natural world of the sixth extinction. It moves beyond the generalisations of the food/environment conflict and details the effects of our thoughts and actions on human ecology. The Macrobiome is the totality of abiotic and biotic life on planet Earth. It is a self-generating organism that has a relentless urge to create life. There have been five complete extinctions in the history of the planet, and yet life reappears. All past extinctions have happened due to natural catastrophes. A new extinction is now on the horizon, caused by human action. The unravelling of the web of life can only be repaired by making peace with planet Earth. One simple yet surprising link to a better future lies in our most intimate relationship to the planet - the food we eat. The choices we make about the foods we eat define our health and our relationship with nature. Our common choices are unfortunately made for reasons of emotional habit, bad science, cultural myth and commercial hubris. This book explores the popular narratives, exposes the outcomes, and provides practical solutions to the present confusion about what we put on our plates.