This is over a 200 year cumulative study of the Myers families of 1700-1800 S.C. with frequent mention of their neighbors. It begins with land acquisitions in the Queensborough District and Welch Grant. John Myers' descendants are all proven by Y-DNA. Previously unrecorded marriages and family relationships are revealed. Although concentrated in the Jeffries Creek area of SC, it follows Myers/Miers descendents into Georgia, Alabama, and Mississippi until the mid 1800s and 1900's. Hundreds of other families are mentioned with land locations. There is considerable information about the families of Burris, Cusack, Bass, Prothro, Nettles, James, McPherson, Simmons, Chandler, and Burch. Discussed are River Road, Middle Swamp, Alligator Swamp, Muldrow’s Mill, Gardner’s Mill, Alligator Road, Claussen, Sparrow Swamp, Lake Swamp, Black Creek, Lynches River, and The Great Pee Dee River. Pioneers of Elbert & Hart Counties of Georgia and Pike, Barbour & Dale Counties of Alabama are presented.