The field of regenerative medicine which includes regenerative orthopedics, is emerging rapidly. Most clinicians in practice did not learn about regenerative medicine during their training and are looking to build a clinical knowledge base. Following in the tradition of its predecessor, this book uses concepts to help clinicians further build upon scientific evidence for nutritional therapies. With 30+ experts weighing in on food and nutrient strategies to improve surgical and nonsurgical outcomes for musculoskeletal conditions, this new edition provides information on how optimizing metabolic pathways can improve the success of regenerative therapies. "What struck me about this book project is how powerfully innovative it is. It builds interdisciplinary collaborations to robustly support practical therapies to manage pain and regain strength. Even more, the collaboration continues beyond this current text. Readers may contact authors through BetterOrthopedics.com. This provides the reader with additional access to the expert book chapter authors. This is truly a unique and significant aspect of this book!" - Gerard A. Malanga, MD; Clinical Professor, Rutgers School of Medicine; President-Elect for the Interventional Orthopedic Foundation for 2019-2020 "I am ecstatically overwhelmed by the knowledge that is found within its pages. Whether you are a patient and especially if you are a caregiver for musculoskeletal injuries and condition, this book is a must read! I believe wholeheartedly that as we follow the information given in this book we will revolutionize how we treat patients with musculoskeletal conditions." - Ethan Kellum, MD, Sports Medicine Trained Orthopedic Surgeon "Living in a state where the opioid crisis has reached epidemic proportions, I found Dr. Kohlstadt's book timely in providing an evidence-based framework. I certainly have high recommendations for this textbook for my colleagues." - Melissa Gamponia, MD, MPH, Family Physician "This book will make your practice not just more enjoyable but totally prosperous as well." - A.J. Medina, MD, MBA, Orthopaedic Surgeon and Surgical Business consultant to Advanced Integrative Regenerative Medicine, Sarasota, Florida "A forward-thinking and highly practical array of therapeutic options available to all orthopedic patients including companion animals, making it an absolute must-have resource for clinical veterinarians." - Rebecca Krimins, DVM, MS, Assistant Professor, Co-Director, Center for Image-Guided Animal Therapy, Johns Hopkins University "A tour de force from outstanding scholars & thought leaders. Together this elite team affiliated with top-notch academic centers of excellence has put together a tome which is a delight to read and reflect upon as well as a source for much knowledge, excitement and anticipation as to the ever-growing promise of metabolic and regenerative medicine." - Mehrdad Michael Massumi, MD, Physical Medicine and Rehabilitation "Practical clinical translation based on a truly personalized approach--each patient as an n of 1. The bevy of new expert authors in this 2nd edition combine for a substantive, relevant and actionable textbook for today's clinicians." - Glenn Sabin, President of FON Consulting, and author of n of 1 "Compelling expert-led clinical research for those utilizing or interested in embracing the latest regenerative technologies." - Nelson Rodriguez, President, RMC Orthopedic and Surgical Inc. PREFACE Enabling a personalized approach Medicine is personalized. The best of clinical medicine draws from all available resources to tailor a treatment for each patient. The gold standard of medical care is and should be an n of 1, epidemiologically speaking. This textbook explores what it means to deliver n of 1 care to patients with musculoskeletal conditions? One characteristic of personalized medicine is that assessment reaches beyond population averages. Selection and dosing of prescription medications involves individual patient data such as genetics, environmental exposures, lifestyle and metabolomics. The timing of and the need for palliative surgery considers emerging therapies such as photobiomodulation, biotensegrity, teledontics and molecular regenerative approaches. Additionally, pain control for often chronic musculoskeletal conditions is opioid-sparing because treatment can be more precise by modifying the patient's specific metabolic pathways. Why proactive orthopedics works Personalized medicine enables prevention. It allows patients to participate more fully in their care, effectively replacing reactive approaches to orthopedics. Proactive orthopedics works with the body's innate healing mechanisms. We know that ancient physicians of both East and West marveled at the powerful healing from within elicited by diet, lifestyle and simple metabolic approaches. Today we see emerging technologies buttressing Antiquity's practice of observing, describ