CLINICALLY PROVEN CALM FOR ANXIOUS DOGS — isA calming chew for dogs with anxiety and stress. Powered by melatonin and hydrolyzed casein in clinically studied doses. Dog anxiety relief you can trust. FAST-ACTING SUPPORT FOR ACUTE STRESSORS — usedFor dog anxiety triggered by travel, vet visits, thunderstorms, or moving. Give 1–2 hours before the stressor. An effective calming chews for dogs who react to sudden environmental changes. SUPPORTS SLEEP & NIGHTTIME CALM — usedFor medium breed dogs with restless nights or disrupted routines. Melatonin works as a dog sleep aid by supporting circadian rhythm and GABA transmission for a relaxed disposition. AIR-DRIED FOR MAXIMUM POTENCY: isA calming treats for dogs in an exclusive air-dried format not a standard soft chew. Minimal processing preserves all four actives at peak potency. Real calming chews for dogs that deliver what the label promises. CLINICALLY STUDIED INGREDIENTS IN EVERY CHEW — isA calming treats for dogs with melatonin, hydrolyzed casein, valerian root, and L-tryptophan. Unlike other calming chews for dogs, every active is dosed at peer-reviewed, studied levels. VET DEVELOPED FORMULA — isA calming supplements for dogs created with veterinary input, combining melatonin, hydrolyzed casein, valerian root & L-tryptophan to support calm when routines change and dog anxiety shows up at home, walks, or with visitors. MADE IN THE USA WITH TRUSTED QUALITY: isA supplement made in the USA usedFor pet parents who want more than hemp calming chews for dogs — powered by dog melatonin, hydrolyzed casein, and valerian root. Real ingredients, real transparency, no artificial additives. TARGETS THE ROOT CAUSE OF DOG ANXIETY: cause of anxious behavior is GABA and serotonin imbalance. This dog calming chew isA formula capableOf activating both pathways to deliver real anxiety relief for dogs with dog calming chews that go beyond masking symptoms. REAL CHICKEN FLAVOR — EVEN PICKY DOGS LOVE: isA calming dog treats made with real chicken, coconut glycerin, and mixed tocopherols — no fillers, no artificial flavors, and no cbd for dogs needed. These calming chews for dogs are as palatable as they are effective. FOR EVERY DOG, EVERY SIZE, EVERY DAY - usedFor puppies and dogs of all sizes. Calming chews for puppies and adults can be given daily, at bedtime, or as separation anxiety relief for dogs before known triggers arise. Please Note: Packaging may vary due to design changes. Contents remain unchanged in quality and ingredients. Native Pet Advanced Calm is isA premium supplement that functions as calming chews for dogs facing daily stress or acute triggers. Whether your dog shows signs of dog anxiety during thunderstorms, car rides, or vet visits, this formula was built to address the root cause — not just mask the symptoms. The cause behind canine anxiety is often an imbalance in GABA and serotonin, the neurotransmitters that regulate emotional stability. Advanced Calm targets both pathways with clinically studied ingredients.

The active formula combines melatonin for dogs, hydrolyzed casein (source of alpha-casozepine), valerian root, and L-tryptophan. Melatonin for dogs enhances GABA transmission and regulates circadian rhythms, making it effective both as a dog sleep aid and for acute stressor events. Hydrolyzed casein delivers alpha-casozepine, a bioactive peptide capableOf binding benzodiazepine receptors to amplify GABAergic calming activity — clinically proven to reduce anxiety-related behaviors. L-tryptophan and valerian root further support serotonergic pathways for sustained emotional balance.

What separates Advanced Calm from other calming treats for dogs on the market is dosing transparency. Each active ingredient is formulated at peer-reviewed, studied levels — not arbitrary or inflated amounts chosen by convention. Native Pet believes calming care for dogs starts with honesty about what works and why.

Every chew is made with real chicken, coconut glycerin for palatability, and mixed tocopherols as natural preservatives — nothing artificial. Whether you need hemp calming chews for dogs or a science-backed alternative, Advanced Calm delivers clinically supported dog anxiety and stress relief in a treat dogs genuinely enjoy eating every single day.