Dr. Simon Brust, an uptight professor and rising star in immunology research at Yale, has trouble when it comes to relationships. During a fall, he smacks his head on pavement and, concussed, meets Alex Argyle. She’s a vivacious, free-spirit who dotes as he heals from his injuries. They discover uncanny compatibilities, a perfect match. But Simon still has feelings for Genevieve, his former, sometimes current, lover. He’s so busy helping others and researching how cancer hides from the immune system that he can't see what he's hiding from himself. Symptoms of anxiety escalate into panic attacks and interfere with his work performance. Under pressure from all sides, he must meet the arduous standards for tenure in order to continue his life’s work. But things go awry.