I. INTRODUCTION Endoscopy of the gastro intestinal tract is a simple safe and well tolerated procedure and in combination with biopsy plays an important role in the early diagnosis of whole GI tract neoplasms. This study was done to determine the histopathologic spectrum of Lower Gastrointestinal Tract (LGIT) Mucosal Biopsies. II. MATERIALS AND METHODS A retrospective study of lower GI endoscopic biopsy was carried out in our tertiary care hospital over a span of two year in which about 74 mucosal biopsies were evaluated byhistopathological examination. III. RESULT Of the 74 patients, 50 (67.6 %) were male and 24 (32.4 %) were female, giving a male to female ratio of 2.11. The 3 most common sites of biopsy were colon > rectum > multiple sites. Of the pathological lesions diagnosed, inflammatory lesions were the most common followed in order by polyps, IBD, malignancy and miscellaneous.16.2 % of biopsies showed normal histology. IV. CONCLUSION The combination of clinical data, endoscopy and histopathology allows for accurate classification of the lesions of lower gastro-intestinal tract in the majority of cases.