Developed by EPA to support its field inspectors, this manual helps readers preparing for compliance-monitoring inspections of manufacturing, processing, distribution, use, and disposal of chemicals. It contains detailed inspection guidance for ensuring compliance with TSCA Sec. 5 (DMN), Sec. 8 (Recordkeeping & Reporting), Sec. 4 (Testing), Sec. 12 (Exports), and Sec. 13 (Imports). This manual also includes a review of the biotechnology program under TSCA.