This 55-page "handbooklet" is intended for anyone at any level who wishes to have more intuitive explanations of the concepts of standard deviation and variance, as well as a better understanding of their formulas and associated concepts. (Total of 66 pages.) Part 1 explains the concepts of standard deviation and variance as measures of variation. Section I.1: Introduction and the Mean Section I.2: Standard Deviation of a Population Characteristic Section I.3: Standard Deviation of a Sample Characteristic Section I.4: Variance Part 2 explains some additional statistical concepts specifically associated with standard deviation and variance, such as degrees of freedom. Section II.1: Unbiased and Biased Estimate Section II.2: Degrees of Freedom Section II.3: Distribution of Measurement Values Section II.4: Point Estimate, Confidence Interval Estimate, and Standard Error of an Estimate Section II.5: Independent Variable and Dependent Variable Part 3 provides a practical exercise to demonstrate the concepts of standard deviation and variance, as well as simple statistical tests, such as the t-test and F-test, to compare the characteristics between two groups. Strength of Association Measures are also examined. Section III.1: Introduction to the Exercise and Calculations to Obtain the Standard Deviation and Variance Section III.2: Comparing Two Groups Section III.3: Strength of Association Measure Part 4 provides information about Research Procedure. Section IV.1: Outline of Research Procedure Section IV.2: Null Hypothesis and “p value” In addition to the explanations of standard deviation, variance, and some other concepts directly associated with these measures of variation, additional statistical concepts are mentioned to lead and encourage the reader to further explore the details of those useful statistical tools that are beyond the scope of this little “handbooklet.” Ray L. Winstead has a bachelor's degree in mathematics (with an additional concentration beyond a minor in biology) from Atlantic Christian College (now Barton College in Wilson, North Carolina), a master's degree in mathematics (with a minor in applied mathematics) from Duke University (Durham, North Carolina), and a Ph.D. in Zoology (with a minor in ecology) from North Carolina State University (Raleigh, North Carolina). He was also a Postdoctoral Fellow for two years in biomathematics and statistics at North Carolina State University. He was a Professor of Biology at Indiana University of Pennsylvania in Indiana, Pennsylvania, where he taught graduate courses in biostatistics and ornithology, as well as undergraduate courses in general biology and ornithology. He retired in June 2013 from IUP after teaching there for thirty-seven years. He is the editor of the book Our First Sixteen Presidents: 110 Portraits, Paintings, and Lithographs with Biographical Narratives by Franklin P. Rice (1882) and Henry W. Rugg (1888) published in January 2014 and also the editor of the book The Development of Law Pertaining to Desegregation of Public Schools in North Carolina: Circumvention of the Supreme Court's 1954 Brown v. Board of Education Ruling for Ten Years in North Carolina (1966 dissertation) by Elton D. "E. D." Winstead published in September 2014.