The Logos concept has a major importance in theology, philosophy and sciences. The main motivation for this dissertation is the first verse in John’s Gospel: ‘In the beginning was the Word (Gr. Logos)’. Logos had more meanings, as (1) a designer’s expressed thinking leading to the creation of a system, and logos as (2) a system descriptor ( system logos ), containing the designs ( form in Greek thinking) of its components plus their logical relations . A logos from the designer’s expressed thinking and the system logos that corresponds to it are similar in essence. The Universe Designer’s expressed thinking was considered the Universe Logos . The first part is a study about the concepts of Word of God and Wisdom from Old Testament as a possible precursor of the Logos concept, about the development of the concept by Greek thinkers, and about the presentation of Lord Jesus as Logos by apostles and Christian apologists, to assert His Deity. We study the Logos concept with the goal of making it accessible in layman terms and to prepare for our discussion about logos and science. In the second part , we present how logos correlates with contemporary science that put emphasis on information and relations, mostly in biology and physics. Also in software, Object Oriented Modeling uses forms (as classes ) & their relations, thus supporting the logos culture. Logos has a personal aspect, through the designer, and an informational aspect, through the system description. We suggest that the informational aspect could be discussed with information science terms. We also suggest based on software design, that for any systems’ design (man-made or natural) logos is essential. This observation corresponds with John’s statement ‘all things were made through Logos’ .