A notorious New Orleans cocaine trafficking covenant, an intrepid Department of Homeland Security Investigations (HSI) office, and a successful family-owned business dynasty unwittingly intersect against a backdrop of a wicked human trafficking enterprise from Mexico into several US cities. In 2024, Shayan Ali, a child of the sixties civil rights movement and a successful cocaine distributor in New Woleans, unexpectedly discovers that the offspring of postwar Italian immigrant entrepreneurs, the Mancinis, located in Maryland, are connected to him through family members. The relationship dramatically upsets the routines of both families and a pending HSI operation. HSI officers in Baltimore, Maryland, and New Orleans, Louisiana, are relentlessly pursuing Ali and Mexican cartel members for their involvement in, among other things, human trafficking. The imbroglio threatens to derail HSI's criminal investigation while placing Ali and the Mancinis in danger of reprisals from Mexican cartels.