Stop memorizing drug facts. Start thinking like an expert psychiatric prescriber. New graduate PMHNPs and nursing students face a critical gap: knowing psychopharmacology theory doesn't prepare you for real-world clinical decision-making. This comprehensive workbook bridges that gap with realistic case studies that teach you to think through complex psychiatric medication decisions with confidence. Master clinical reasoning for psychiatric prescribing across all major disorders: Depression cases including treatment-resistant depression, perinatal depression, and depression with medical comorbidities. Learn first-line treatment selection, augmentation strategies, and when to escalate care. Anxiety and trauma disorders from GAD and panic disorder to PTSD and OCD. Practice distinguishing between anxiety types, optimizing SSRI/SNRI therapy, and appropriate benzodiazepine use. Bipolar disorder management including acute mania, bipolar depression, rapid cycling, and medication adherence challenges. Choose between lithium, valproate, lamotrigine, and antipsychotics with evidence-based rationales. Psychotic disorders from first-episode schizophrenia to treatment-resistant cases requiring clozapine. Navigate first vs. second-generation antipsychotic selection, metabolic monitoring, and managing negative symptoms. ADHD in adults with comorbid conditions plus substance use disorders including alcohol, opioids, and dual diagnosis cases. Master stimulant prescribing, medication-assisted treatment protocols, and harm reduction approaches. Special populations requiring modified approaches: Pediatric and adolescent psychiatric prescribing with careful monitoring protocols. Geriatric cases addressing cognitive impairment and polypharmacy concerns. Pregnancy and lactation medication safety decisions balancing maternal and fetal health. Patients with renal or hepatic impairment, cardiac conditions, and complex medical comorbidities. Each case includes: Detailed patient presentation with history, symptoms, and assessment data. Systematic differential diagnosis with reasoning for inclusion and exclusion of each possibility. Evidence-based treatment algorithms showing first-line, second-line, and third-line options. Specific prescribing details including starting doses, titration schedules, and target doses. Monitoring protocols for efficacy assessment and side effect surveillance. Patient education scripts explaining medications, managing expectations, and safety information. Comprehensive answer key with clinical rationales: Complete differential diagnoses with red flags that shouldn't be missed. Treatment selection rationale based on patient-specific factors. Expected timeline for therapeutic response and when to adjust. Laboratory monitoring requirements and frequency. Common prescribing errors and how to avoid them. References to current APA, CANMAT, and NICE guidelines. Learn the clinical reasoning framework expert prescribers use: Hypothetico-deductive model for generating and testing diagnostic hypotheses. IDEA critique method for evaluating your clinical decisions. Risk-benefit analysis for medication selection. Measurement-based care using PHQ-9, GAD-7, MDQ, and other validated tools. Cognitive bias recognition and mitigation strategies. Apply evidence-based psychopharmacology to real scenarios: Cases organized by disorder with increasing complexity. Treatment-resistant cases requiring advanced strategies. Comorbidity management addressing multiple conditions simultaneously. Drug-drug interactions and pharmacokinetic considerations. Cultural and capacity considerations in prescribing. This workbook transforms passive learning into active clinical reasoning practice.