No Programming Required and it works straight out of the box after installing the new batteries (not included). Please note: it does Not work with Streaming Box Players, Stick Players. Compatible with All TCL Roku TV Models: 06-IRPT20-TRC280J 40S321 43S421 50S421 55S421 70S42 50S421 32S321 43S421 65S421 32D2900 55D2900U 65D2930U 65S4 32S301 40FS3700 55S401 65S401 43S403 49S403 55S403 65S403 43S515 55S425 49S515 55S515 65S515 55R615 65R615 55P605 55C803 65C803 75C803 40S303 43S303 49S303 40S3750 48S3750 55S3750 50S3800 50FS3750 55FS3800 50FS3700 49S405 32S305 55S403 65S403 43S515 49S515 55S515 65S515 55R615 65R615 55P605 55C803 65C803 75C803 40S303 43S303 49S303 40S3750 48S3750 55S3750 50S3800 50FS3750 55FS3800 50FS3700 49S405 32S305 40FS4610R 43S405 32S3750 40S305 43S305 55S405 40FS4610R 43S405 32S3750 40S305 43S305 55S405 32FS4610R 32S800 32S3850B 40S3800 55US57 50UP120 28S3750 49S305 65S405 50FS3800 40FS3750 32S3850P 40FS3850 50FS3850 48FS3750 55FS4610R 55UP120 32S4610R 55US5800 65US5800 55FS3750 32S3700 32S3800 48FS3700 55FS3700 32S850 32S3850 32S3850A 28S305 55FS3850 40FS3800 48FS4610R 43FP110 49FP110 50FS3750 32FS3700 32FS4610R 32S800 32S3850B 40S3800 55US57 50UP120 28S3750 49S305 65S405 50FS3800 40FS3750 32S3850P 40FS3850 50FS3850 48FS3750 55FS4610R 55UP120 32S4610R 55US5800 65US5800 55FS3750 32S3700 32S3800 48FS3700 55FS3700 32S850 32S3850 32S3850A 28S305 55FS3850 40FS3800 48FS4610R 43FP110 49FP110 50FS3750 32FS3700 65S421 43S425 50S425 55S425 65S425 32S321 40S321 43S421 50S421 55S421 75S425 32D2900 55D2900U 65D2930U 65S4 32S301 40FS3700 55S401 65S401 43S403 49S403 RC280 Remote Control Replacement for TCL ROKU Smart Televisions with Netflix, CBS ALL ACCESS, Roku Channel, Google Play Shortcut Keys Compatible with Below TCL TV Models: 06-IRPT20-TRC280J 40S321 43S421 50S421 55S421 70S42 50S421 32S321 43S421 65S421 32D2900 55D2900U 65D2930U 65S4 32S301 40FS3700 55S401 65S401 43S403 49S403 55S403 65S403 43S515 55S425 49S515 55S515 65S515 55R615 65R615 55P605 55C803 65C803 75C803 40S303 43S303 49S303 40S3750 48S3750 55S3750 50S3800 50FS3750 55FS3800 50FS3700 49S405 32S305 40FS4610R 43S405 32S3750 40S305 43S305 55S405 32FS4610R 32S800 32S3850B 40S3800 55US57 50UP120 28S3750 49S305 65S405 50FS3800 40FS3750 32S3850P 40FS3850 50FS3850 48FS3750 55FS4610R 55UP120 32S4610R 55US5800 65US5800 55FS3750 32S3700 32S3800 48FS3700 55FS3700 32S850 32S3850 32S3850A 28S305 55FS3850 40FS3800 48FS4610R 43FP110 49FP110 50FS3750 32FS3700 32S321 40S321 43S421 50S421 55S421 65S421 43S425 50S425 55S425 65S425 75S425 32D2900 55D2900U 65D2930U 65S4 32S301 40FS3700 55S401 65S401 43S403 49S403 55S403 65S403 43S515 49S515 55S515 65S515 55R615 65R615 55P605 55C803 65C803 75C803 40S303 43S303 49S303 40S3750 48S3750 55S3750 50S3800 50FS3750 55FS3800 50FS3700 49S405 32S305 40FS4610R 43S405 32S3750 40S305 43S305 55S405 32FS4610R 32S800 32S3850B 40S3800 55US57 50UP120 28S3750 49S305 65S405 50FS3800 40FS3750 32S3850P 40FS3850 50FS3850 48FS3750 55FS4610R 55UP120 32S4610R 55US5800 65US5800 55FS3750 32S3700 32S3800 48FS3700 55FS3700 32S850 32S3850 32S3850A 28S305 55FS3850 40FS3800 48FS4610R 43FP110 49FP110 50FS3750 32FS3700 No programming or paring needed. Install new alkaline batteries to get it work.