USA Today Bestseller Why have you struggled with your weight, even when you did "everything right"? The answer isn't willpower or diet, and it's not you. Your Best Shot provides the tools to optimize your weight-health hormones permanently, whether you have never used a GLP-1 medication, are currently using one, or are ready to come off one. Here's the insight that's reshaping medicine: GLP-1 medications like Ozempic, Wegovy, Mounjaro, and Zepbound work because the body regulates appetite, metabolism, blood sugar, and fat storage through a sophisticated hormonal system. If a medication helped you lose weight or curb cravings, it means your own weight-health hormones weren't functioning at their best. That's not a personal failure. That's biology, and it's fixable—with or without the shot. Registered dietitian and weight health pioneer Ashley Koff, RD has spent over two decades in clinical practice developing a system that finally addresses why weight loss doesn't often work long-term, and what actually does. The result is an evidence-based, personalized program that meets you exactly where you are. This is not another weight loss plan. This is your plan. With Your Best Shot , you will: Identify why your weight-health hormone function isn’t optimal —and how to fix it - Personalize the nutrition and lifestyle plan with food, supplement, activity, and sleep guidelines - Eliminate food noise and decision fatigue by finding out what information to ignore and what to trust - Navigate the landscape of GLP-1 medications, supplements, and foods - Build a sustainable reset , because life happens, so your plan needs to adjust with it Your Best Shot is essential for the millions of people using GLP-1s who want to maximize their results, protect their progress, and build a foundation that lasts long after the medication. It is also the definitive guide for anyone considering coming off GLP-1 therapy who needs a plan that works without it. If you've struggled with weight, cravings, energy, or body composition, this book was written for you. "Ashley is one of the most insightful and trusted nutrition experts I know—there is no one I trust more to train practitioners and guide patients. Your Best Shot puts Ashley’s wisdom and knowledge into practice—it’s the weight management tool we have been waiting for.  " - Tieraona Low Dog, MD, ABOIM, Director, Integrative & Functional Medicine Fellowship, UC-I Susan Samueli Integrative Health Institute "With growing interest in GLP-1 therapies, it’s more important than ever to have a guide you can trust. Your Best Shot is that guide: thorough, precise, compassionate. Ashley Koff RD gives you more than just protocols, she gives you the tools to understand your own body and to choose what works best for you." - Frank Lipman MD, New York Times bestselling author "A practical, science-based guide to weight health. Ashley Koff RD translates complex hormone science into clear, actionable steps—no gimmicks, just results. She’s an expert I trust, and now you can too." - JJ Virgin CNS, CHFS, New York Times bestselling author "Timely, engaging, and empowering. Overcoming—the challenges of losing weight you don't want, finding health you do—begins with understanding, and you will find that here in delightful abundance." - David L. Katz, MD, MPH, Past President, American College of Lifestyle Medicine;Founder, Diet ID "After decades of books that treat everyone the same, Your Best Shot emerges as a breakthrough. Ashley Koff RD’s new work recognizes that weight health is not one size fits all: it’s about weight-health hormones, total nutrition, lifestyle choices, genetics and more. The strategies are evidence-based, actionable, and rooted in real clinical practice. Our patients have benefited tremendously from this approach, and I am thrilled it is now available for everyone's benefit." - Darshan Shah MD, CEO and founder Next Health Your Best Shot is a revolutionary personalized approach to weight management. Ashley Koff, RD, who is recognized as a leading nutrition innovator, has delivered her unique skills and clinical experience in this important book that provides a successful approach to weight loss in the age of GLP-1 medications. This book is a must-read for anyone trying to make sense of how to manage their weight. - Jefferey Bland, PhD, President of Big Bold Health In Your Best Shot, Ashley Koff RD gives you the manual and rationale for conducting your n:1 experiment to optimize your metabolic hormones for better overall health. It's a valuable tool for patients and practitioners alike. - Sara Szal MD, bestselling author of Women, Food, and Hormones With humor, precision, and years of experience Ashley Koff RD serves as your detective pointing out clues to explain the challenge of healthy, sustained weight loss and providing a clear road map for success! - Victoria Maizes, MD, Founding Executive Director, Andrew Weil Center for Integrative Medicine and author